How Long is Methadone Withdrawal?

Medically Reviewed by
Nzinga Harrison, MD
October 4, 2021

Overdose is the leading cause of unintentional death in the U.S. However, this issue has only worsened after the COVID-19 outbreak. According to the Centers for Disease Control and Prevention (CDC), about 81,230 people died of an overdose in the U.S. from June 2019 to May 2020, the highest ever recorded in 12 months. And opioid use disorder (OUD) appears to be the main cause behind such overdose deaths.  

The medical community has successfully identified and initiated various measures and treatment options to help fight the opioid crisis. And one of such treatment options is medications for opioid use disorder (MOUD), such as methadone. Methadone maintenance treatment (MMT) has shown considerable success and is increasingly used to help individuals struggling with an OUD live healthier sober lives. However, methadone’s risk of causing dependence and withdrawals has raised serious concerns regarding its efficacy as a treatment option. 

What Is Methadone?

Methadone, sold under brand names Methadose and Dolophine, is a prescription medication used to treat moderate to severe pain and opioid use disorder. Methadone was first approved by the U.S. Food and Drug Administration (FDA) to treat OUD in the late 1970s. Methadone is a synthetic opioid medication that functions by interacting with opioid receptors in the brain to reduce symptoms of opioid withdrawals. MMT is most effective when used in conjunction with behavioral therapies and counseling. 

Methadone is a highly regulated medication that can only be prescribed through a methadone clinic. It is regarded as the gold standard for opioid dependence treatment and is included in the World Health Organization’s list of essential medicines. 

According to the Substance Abuse and Mental Health Services Administration (SAMHSA), methadone is a relatively safe and effective medication when used as prescribed. However, since it’s still an opioid, prolonged use increases the risk of tolerance, dependence, and addiction to the medication. 

Side Effects of Methadone Withdrawal 

The addictive nature of methadone may cause individuals to experience withdrawal symptoms upon quitting the medication abruptly. After prolonged use, the sudden absence of methadone triggers uncomfortable reactions while the body relearns to function without the medication again. 

Symptoms of methadone withdrawal are similar to withdrawal from other opioids such as heroin and morphine but are usually moderate and flu-like. Some of the most common symptoms of methadone withdrawal are:

  • Chills
  • Fever
  • Anxiety 
  • Runny nose 
  • Watery eyes 
  • Excessive sweating
  • Muscle aches and pains 
  • Nausea
  • Vomiting 
  • Rapid heartbeat
  • Stomach cramps 
  • Irritability
  • Paranoia
  • Diarrhea
  • Cravings 
  • Insomnia 
  • Hallucinations 
  • Depression 

Methadone withdrawal can be a painful experience. Hence, individuals receiving MMT are gradually weaned off the medication at the end of their MOUD treatment under the guidance and supervision of their healthcare provider. 

Methadone Withdrawal Timeline 

Methadone withdrawal symptoms usually appear within 24-36 hours after the last dose due to the long-acting nature of this medication. However, some may not even experience withdrawal symptoms until several days after the last dose. Symptoms of methadone withdrawals are most distressing during the first seven to 10 days of detox. 

Methadone withdrawal typically follows the below timeline:

  • Days 1-2: People may experience physical symptoms such as chills, fever, rapid heartbeat, and muscle aches during this initial withdrawal stage. 
  • Days 3-8: Methadone craving and other symptoms of withdrawal peak over the first week. Other symptoms may include anxiety, body aches and pains, nausea, insomnia, and irritability. Additional symptoms such as depression, vomiting, and cramps may also appear during this period. 
  • Days 9-15: Symptoms will begin to subside during this period, although some symptoms such as irritability, diarrhea, and physical discomfort are likely to remain. Cravings for methadone can still be strong, and some people may also experience a worsening of depression. 
  • Week 3: Methadone withdrawal symptoms such as low energy, anxiety, sleeping troubles, and cravings may persist for 2-3 weeks since the last dose. Most people may also experience post-acute withdrawal syndrome (PAWS) after 3-6 weeks. PAWS can last for several months or even up to 2 years and include symptoms such as irritability, anxiety, depression, insomnia, poor concentration, and the inability to feel pleasure. 

How Long Is Methadone Withdrawal?

Methadone withdrawal is a slow and relatively long process. Withdrawal symptoms begin within 24-36 hours, peak within 7-10 days, and last anywhere between 2-3 weeks to up to six months.  However, the withdrawal duration and severity can vary from person to person based on factors such as:

  • The duration of methadone use
  • The frequency of methadone use
  • The dose of methadone consumed
  • The method of consumption 
  • The severity of methadone addiction  

A person who uses methadone as prescribed for three months will generally go through a shorter withdrawal process than someone who has been using methadone for a year or misusing methadone in large doses. 

Methadone Withdrawal Cold Turkey – Is It Safe?

Quitting methadone cold turkey is not life-threatening in most instances, but it’s not recommended. Methadone can cause severe withdrawal symptoms and hinder the recovery process. One of the biggest risks of quitting methadone cold turkey is its potential to cause a relapse. It can also trigger health complications that may require immediate medical attention, such as dehydration and electrolyte imbalance from vomiting, diarrhea, and aspiration from breathing stomach contents into the lungs. Thus, people are advised not to quit methadone cold-turkey and seek a healthcare provider’s services to wean off the medication safely instead.  

How to Manage Methadone Withdrawal?

The safest and most efficient way to detox from methadone is to undergo a tapering-down program under the supervision of a medical professional. A tapering-down program involves reducing methadone doses over a certain period rather than quitting it cold-turkey to manage methadone withdrawals. Methadone clinics generally provide people with such services at the end of treatment to ensure that they wean off the medication safely and successfully. 

Some doctors may utilize certain medications during detox to ease symptoms of methadone withdrawal and shorten the duration of detox. Medical detox can include the use of medications such as Zofran, clonidine, and baclofen to mitigate anxiety, agitation, high blood pressure, nausea, and muscle pains. 

During the weaning process if you decide you would like to continue being on opioid replacement therapy such as suboxone, this can be done if planned ahead with your medical provider 

Although withdrawal from any addictive substance can be difficult, the long-term benefit of using methadone for opioid dependence treatment far outweighs its risks. 

If you are seeking help with your loved one’s addiction, contact us today or complete our quick contact form below, to speak with an addiction treatment specialist.

If you need help with your substance use disorder, we are here to help you build your confidence and momentum towards the future you want. We provide treatment services for adults with alcohol, opioid, and other substance use disorders. We are currently located in Florida, LouisianaMassachusettsNew JerseyNorth CarolinaOhio, Texas, and Washington.

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Nzinga Harrison, MD

Dr. Harrison serves as the Chief Medical Officer for Eleanor Health with more than 15 years experience practicing medicine. She is a double-board certified physician with specialties in general adult psychiatry and addiction medicine. Dr. Harrison has spent her career as a physician treating individuals from marginalized communities with substance use and other psychiatric disorders. As a physician executive, she has served as Senior Vice President and Chief Medical Officer roles committed to creating and improving systems-based delivery of psychiatric and substance abuse care. She is a vocal advocate for stigma reduction, and is passionate about the necessity for whole-person care as individuals and communities seek to recover from and prevent substance use disorders.

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