Side Effects of Lexapro

Medically Reviewed by
Marisa Savic, PMHNP-BC
October 10, 2023

When depressed, anxious, or going through a period of extended stress, your doctor may prescribe Lexapro as a treatment. The medication is designed to help regulate serotonin levels in the brain, which can help ease symptoms of depression and anxiety.

But, like all medications, Lexapro can also carry a risk for certain side effects. Knowing what to watch out for is important when taking this medication. In this article, we’ll discuss the most common side effects of Lexapro.

What is Lexapro?

Lexapro (escitalopram) is a medication used to reduce anxiety and improve symptoms of depression. It belongs to a class of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs) that work by increasing serotonin in the brain. Stable serotonin levels can improve sleep, memory, appetite, mood and anxiety.

Who Can Take Lexapro?

Lexapro is approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder and generalized anxiety disorder. Below are symptoms that occur with those diagnoses:

Major Depressive Disorder

  • Feeling sad, empty or hopeless
  • Not feeling interested in or enjoying things that you used to like
  • Difficulty concentrating on everyday tasks
  • Low self-esteem or excessive guilt about things
  • Pessimism about the future
  • Thoughts about death
  • Insomnia or oversleeping
  • Overeating or undereating, which can lead to weight changes
  • A constant feeling of fatigue

Generalized Anxiety Disorder

  • Unexplained fear or excessive worry
  • Agitation or restlessness
  • Irritability or becoming easily annoyed
  • Trouble relaxing
  • Issues falling or staying asleep
  • Brain fog or difficulty thinking clearly

Lexapro can also be used off-label (not approved by the FDA) for other mental health diagnoses including obsessive-compulsive disorder, post traumatic stress disorder, panic disorder, social anxiety disorder and some eating disorders. 

There are certain populations that require close monitoring or adjustments when using this medication. For children, teenagers and young adults, antidepressant medications like Lexapro can lead to increased suicidal thoughts and therefore these age groups should be monitored closely if receiving this medication. For individuals who have been diagnosed with bipolar disorder, Lexapro and other antidepressant medications should be avoided or require a concomitant mood stabilizing medication. Individuals with heart, kidney, liver or seizure issues may require close monitoring or dosage adjustments. People who are pregnant or breastfeeding should speak with a provider about risks for transmitting Lexapro to the infant and whether it is safer to treat symptoms with or without the medication. Finally, older adults taking Lexapro require reduced dosing to prevent excessive or dangerous side effects.

Common Side Effects of Lexapro

Lexapro is a safe and effective option for treating depression and anxiety. However, using this medication isn’t risk-free, and risks/benefits should be discussed with a prescribing provider before initiating treatment. It should also be noted which side effects are most likely to occur and if they will dissipate over time.

A list of the physical,, mental, and rare but serious side effects of Lexapro

Physical Side Effects

The most common physical side effects associated with Lexapro include:

  • Nausea, vomiting, and stomach discomfort
  • Diarrhea or constipation
  • Headache and fatigue
  • Dizziness and lightheadedness
  • Sweating

Less common physical side effects include:

  • Increased appetite/weight gain
  • Dry mouth and excessive thirst
  • Blurred vision
  • Muscle pain and weakness
  • Sexual problems such as delayed ejaculation in men or decreased sex drive

Emotional/Cognitive Side Effects

Common emotional and cognitive side effects of Lexapro include:

  • Insomnia, abnormal dreams or nightmares
  • Apathy
  • Irritability
  • Paranoia

Rare but Serious Side Effects of Lexapro

Although rare, some serious side effects are associated with taking Lexapro. These include:

  • Low sodium levels in the blood (hyponatremia)
  • Abnormal bleeding or problems with platelet counts due to low platelet levels
  • Seizures
  • Allergic reactions include swelling of the face and throat, difficulty breathing or swallowing, rash, itching, and hives.
  • Hallucinations (seeing/hearing things that aren’t there)
  • Delusions (false beliefs about things that are not based in reality)
  • Hypomania/mania (periods of excessive energy or irritability that can lead to extreme risk-taking behaviors and impaired thought processes)
  • Suicidal thoughts

Additionally, taking Lexapro with certain medications or herbs may increase serotonin activity to dangerous levels, leading to serotonin syndrome. This potentially life-threatening drug reaction can cause muscle twitching, fever, and delirium. If you experience any of the symptoms associated with this condition or any of these serious side effects, contact your doctor immediately.

Using Lexapro Long Term

Lexapro is considered safe for long-term management of anxiety and depression symptoms. However, some individuals may experience new or increased side effects when using the medication over an extended period of time. These can include the following:

  • Mental fatigue
  • Memory loss
  • Sexual dysfunction
  • Weight gain or difficulty losing weight
  • Emotional blunting
  • Increased depression/anxiety
  • Withdrawal symptoms

It is essential to discuss the possibility of both short and long term side effects of Lexapro with your mental health provider. To note, periods of excessive anxiety and depression also carry short and long term risks to physical and mental health and should be considered when deciding whether or not to use this medication.

Mixing Lexapro with Other Medications

As stated previously, serotonin syndrome can develop when mixing Lexapro with other medications that can increase serotonin levels. Below is a list of medications that can lead to this interaction when taken with Lexapro:

  • Other selective serotonin reuptake inhibitors (SSRIs) such as 
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs) including duloxetine, venlafaxine and desvenlafaxine
  • Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, phenelzine, tranylcypromine, and selegiline.
  • Tricyclic antidepressants (TCAs) such as amitriptyline, nortriptyline, or clomipramine
  • Atypical antidepressants such as trazodone, mirtazapine, vilazodone, vortioxetine
  • Buspirone
  • Tryptophan, St. John’s Wort, and other herbal supplements
  • Certain pain or migraine medicines such as fentanyl, rizatriptan, sumatriptan, tramadol, Frova, Imitrex, Maxalt, Relpax, Ultram or Zomig

Additionally, other medications can interact with Lexapro and should be discussed with a provider before initiating treatment. Some examples include the following: 

  • Lithium
  • Blood thinners, such as aspirin, NSAIDs (ibuprofen or diclofenac), or warfarin (Coumadin).

It’s essential to speak to your provider before starting any new medications or supplements while taking Lexapro.

Managing Lexapro Side Effects

Most side effects from Lexapro are mild and will usually go away with time. However, there are things you can do to prevent or reduce them.

1. Speak with your provider

Communication with your provider is key to managing side effects and optimizing the effectiveness of Lexapro in treating depression and anxiety. Many people don’t report side effects to their doctor, which can affect their experience with the medication and lead to dropping out of treatment. If you experience any physical or emotional side effects while taking Lexapro, the best approach is to discuss it with your provider and work together on any adjustments that need to be made to reduce them. 

2. Adjusting the medication

To reduce risk for or intensity of side effects, you and your provider may choose to initiate treatment at lower doses or adjust when or how the medication is taken. For example, starting treatment at 5mg a day instead of 10mg can lead to better tolerability. Taking Lexapro in the evening may reduce side effects of daytime sedation or fatigue while taking it in the morning can reduce side effects of insomnia. Additionally, taking Lexapro with food can help reduce gastrointestinal side effects such as nausea. It’s important to work with your provider when adjusting the medication as making changes without prescriber consent can significantly impact treatment.

3. Lifestyle changes/self-care

Engaging in lifestyle changes and self-care techniques can help reduce side effects of Lexapro. Examples of self-care include exercising regularly, drinking plenty of water, eating healthfully, getting enough sleep, taking breaks from work or school, and engaging in relaxation techniques such as yoga, meditation, and deep breathing exercises.


How long does it take for Lexapro to work?

While Lexapro takes a few hours to increase serotonin levels in the brain, it usually takes about 4–6 weeks to experience the full benefit of the medication. Some key signs that Lexapro is working include feeling more energetic, worrying less, having fewer negative thoughts, sleeping better, and feeling more hopeful.

If your depression or anxiety symptoms do not improve after six weeks of taking Lexapro, contact your provider to discuss dosage adjustments, changing medication or using adjunctive treatment.

What should I do if I miss a dose of Lexapro?

If you miss a dose of Lexapro, take it as soon as you remember. If it’s close to your next dose (within a few hours), skip the missed dose and continue your regular dosing schedule. Do not take two doses at once or take an extra dose to compensate for the missed one.

Is it safe to drink alcohol while taking Lexapro?

Not everyone reacts the same way to alcohol when taking Lexapro. The effects of mixing alcohol and Lexapro may depend on the dosage you take and how much you drink. Research suggests that people who take the maximum dosage for depression and anxiety (20mg a day) may have a higher risk for experiencing side effects or complications from drinking alcohol. Finally, drinking while taking psychiatric medication can reduce the efficacy of the medication. Therefore, it’s best to talk to your provider about potential risks and whether or not you should avoid alcohol while taking Lexapro.

With the potential for mild to moderate side effects, it’s important to know what to expect while taking Lexapro. If you experience any side effects, speak with your provider and work on adjustments together.

Let your provider know if you plan on taking any over-the-counter medications or supplements, as some may interact with Lexapro and raise the risk of side effects.

At Eleanor Health, we understand that taking medication for mental health can be challenging and intimidating. If you are currently struggling with an addiction and are worried about your mental health, contact us today to learn more about how we can work together to get you on the path of recovery. 

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Marisa Savic, PMHNP-BC

Marisa Savic, PMHNP-BC is a board certified psychiatric mental health nurse practitioner who received her nursing and master’s degrees at the University of Pennsylvania. Marisa has worked as a provider, clinical manager, director of clinical quality, and program manager of addiction treatment at numerous companies specializing in telepsychiatry as well as working in person at inpatient, outpatient, detoxification and crisis center facilities. She is currently the National Lead Psychiatric Nurse Practitioner at Eleanor Health and her clinical interests include therapeutic communication, evidence-based treatment and nonjudgmental care.

Medication Guide Anxiety Depression Blog Mental Health

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